Conserved Protein Domain Family
ADA

cd01320: ADA

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Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.

Links

Source:	cd00443
Taxonomy:	cellular organisms
PubMed:	1 link

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl00281

Statistics

PSSM-Id:	238645
Aligned:	33 rows
Threshold Bit Score:	363.832
Created:	6-Mar-2002
Updated:	2-Oct-2020

Structure

Conserved Features/Sites?
PubMed References ?

active sitepurine riboside

Conserved site includes 7 residues -Click on image for an interactive view with Cn3D

Feature 1:active site [active site]

Evidence:

Structure:1A4M; adenosine deaminase with bound metal and substrate analog (6-hydroxy-1,6-dihydro purine nucleoside)
- View structure with Cn3D
Citation:PMID 1518061

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Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1              # #                                                                      
2ADA          8 NKPKVELHVHLDGAIKPETILYFGKKRG-IALPadtve-elrniIGMDKPLSLPGFLAKFDYYMPVIAgcREAIKRIAYE 85  house mouse
ZP_00018439  15 DVPLIDLHRHLDGNVRLTTILDVARTYG-IRLPadtveglrpyaQIQGVAASVMDFIARFDLLKLICVd-EDVVARIAEE 92  Chloroflexus aur...
NP_872958     7 QYGVIDLHLHLDGSLSPAWMIEWAKKQA-VNLPastaealtayvSVPQDCSDLNEYLRCFDLPLSLLQt-PEALSSAVTD 84  Haemophilus ducr...
NP_813973     8 QLPKIELHCHLDGSIRPTTLRTIAEKQN-IPLPqdeqa-lkelvVAPEKCTDLNDYLTRFDFVLTCLQt-AEALQAAAYD 84  Enterococcus fae...
Q8E6I0        8 ELAKAELHCHLDGSLSLPAIRKLANMAD-IILPssdke-lrkyvIAPAQTESLVDYLKTFEFIRPLLQt-KEALRFAAYD 84  Streptococcus ag...
Q9X7T2       13 RLPKAVLHDHLDGGLRPATVVELARSVG-HTLPttdpdelaawyYEAANSGDLVRYIATFEHTLAVMQn-REGLLRAAEE 90  Streptomyces coe...
CAE15146      7 LLRKVELHTHLDCGLSYHFVKKFIPDITrKSFCek--------yIAAEKCHDLGDFLNKIIPSLDLLQk-RDVIADAVED 77  Photorhabdus lum...
NP_501087    48 NFPKVELHLHLDGAVRFDTLIDLSQQKG-IPLAgaktveelkkvLVTHEPANLSKVLEAFEIFLPVIRgdLAAIERVAYE 126 Caenorhabditis e...
1KRM_A        7 DKPKVELHVHLDGAIKPETILYYGKRRG-IALPadtpe-ellniIGMDKPLTLPDFLAKFDYYMPAIAgcRDAIKRIAYE 84  cow
1A4M_A        5 NKPKVELHVHLDGAIKPETILYFGKKRG-IALPadtve-elrniIGMDKPLSLPGFLAKFDYYMPVIAgcREAIKRIAYE 82  house mouse

Feature 1                                                                                       
2ADA         86 FVEMKAKEGVVYVEVRYSPHllanskvdpmpwnqtegDVTPDDVVDLVNQGLQEGEQAf-----GIKVRSILCCMRHqp- 159 house mouse
ZP_00018439  93 NVEDAANEGIDYIELRCSPAfmg-----------eryGLDPTRVLAAVCRGVRAGMARy-----PVQAQIIGIMSRHmg- 155 Chloroflexus aur...
NP_872958    85 LIQRLDQDGLVYAEIRFAPQlht------------qrSMSQEDAVKAALRGLQAGLASt----sLFKANLILCCMRAadn 148 Haemophilus ducr...
NP_813973    85 VISQAAEDGVAYIEVRFAPSqht------------ekGLRLPEIVTAVLTGLKQGEEDf-----GVKSNALLCGMRHdq- 146 Enterococcus fae...
Q8E6I0       85 VARQAALENVIYIEIRFAPElsm------------dkGLTASDTVLAVLEGLADAQKEf-----NIVARALVCGMRQss- 146 Streptococcus ag...
Q9X7T2       91 YVLDLAADGVVYGEVRYAPElnt------------rgGLSMREVVETVQEGLATGMAKaaaagtPVRVGTLLCGMRMf-- 156 Streptomyces coe...
CAE15146     78 LFIQLKSDNVVYAEIRFAPLlhl------------rlGLNERDIVEIVLEAMKNYSIKy-----GIAAGLILCTLRNfs- 139 Photorhabdus lum...
NP_501087   127 LCEDQHNNGVVYFEGRYSPHlllc---------ndypEVTAAHVVAAVKKGFDRGEKQf-----GIKARSILCCIRGld- 191 Caenorhabditis e...
1KRM_A       85 FVEMKAKDGVVYVEVRYSPHllanskvepipwnqaegDLTPDEVVSLVNQGLQEGERDf-----GVKVRSILCCMRHqp- 158 cow
1A4M_A       83 FVEMKAKEGVVYVEVRYSPHllanskvdpmpwnqtegDVTPDDVVDLVNQGLQEGEQAf-----GIKVRSILCCMRHqp- 156 house mouse

Feature 1                                                                 #  #                  
2ADA        160 -sWSLEVLELCKKYNQk---tVVAMDLAGDEtiegsslfPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDiLKTER 235 house mouse
ZP_00018439 156 eeSCWRELEAAIALMSe---gVVGIDLAGDEanf---pgTRFVKHFARARAAGLRITVHAGEAAGAWSVRQAIEeLGAER 229 Chloroflexus aur...
NP_872958   149 rsANLETICLAKQYLTkyeagVVAIDLAGAEglf---atQHFQQEFDFANQRGVPFTIHAGEAAGPESVQQALD-FGATR 224 Haemophilus ducr...
NP_813973   147 qqAIEKIVHLAHDFREt---gVVGFDLAGNEvdf---ppYTFEDVLALANQLSIPLTLHAGECGCGKNVADAVT-LGATR 219 Enterococcus fae...
Q8E6I0      147 hkTTKDIIKHIVDLAPk---gLVGFDFAGDEfsy---ptDSLVDLIQEVKRSGYPMTLHAGECGCAKHIADSLN-LGIKR 219 Streptococcus ag...
Q9X7T2      157 -dRVREAADLAVAFRDa---gVVGFDIAGAEdgf---ppADHLDAFEHLRRENVPFTIHAGEAHGLPSIHQALQvCGAQR 229 Streptomyces coe...
CAE15146    140 edQSLRTAYLVNEYSNy---gVVALDLAADEary---plSAHLNAFRMVLENGGNIIAHAGEAKGAESVRETINkLNISR 213 Photorhabdus lum...
NP_501087   192 kkFPQLILDLATDLKQl---gVVAIDVAGSAhgadeqyePEVVAAFQEAHKRGIHRTVHAGESGGPKEVIKAIEdMYAER 268 Caenorhabditis e...
1KRM_A      159 -sWSSEVVELCKKYREq---tVVAIDLAGDEtiegsslfPGHVQAYAEAVKSGVHRTVHAGEVGSANVVKEAVDtLKTER 234 cow
1A4M_A      157 -sWSLEVLELCKKYNQk---tVVAMDLAGDEtiegsslfPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDiLKTER 232 house mouse

Feature 1         #                                                                       ##    
2ADA        236 VGHGYHTIEDe---------aLYNRLLKENMHFEVCPWSSYLTGAWDpk------tTHAVVRFKNDKANYSLNTDDPLIF 300 house mouse
ZP_00018439 230 IGHGVRAVEDp---------aVLQLIAERGVALEVCPTSNVQTQTVSgy------eSHPLPQLLRRGLLVTLNTDDPGIS 294 Chloroflexus aur...
NP_872958   225 IGHGIRAIESe---------tVMKQLIDKRTPLEMCPCSNLQTKTVAql------aDYPLRTFLMRGVVATLNTDNMTVS 289 Haemophilus ducr...
NP_813973   220 IGHGIALKDTp---------eYLALLKEKKVLLEMCPTSNFQTGTVKtl------aEYPFQQFIEAGLAVCINTDNRTVS 284 Enterococcus fae...
Q8E6I0      220 MGHVTALTGQr---------dLIKRFVEEDAVAEMCLTSNLQTKAASsi------qSFPYQELYDAGGKITINTDNRTVS 284 Streptococcus ag...
Q9X7T2      230 IGHGVRITDDipdlaagklgrLAAWVRDRRIALEMCPTSNLQTGAATsi------aEHPITALKDLGFRVTLNTDNRLVS 303 Streptomyces coe...
CAE15146    214 IGHGVRSIEDr---------dVIELLIERNIHLEVCPTCNIICDIYDiydiydiyeNHPVNFLKEVGVNIGINTDARTVA 284 Photorhabdus lum...
NP_501087   269 IGHGYRVMRDee-------myLEHFVNSKNVHLEACPYSSVMTGAVPld-----wkNHPIARWAKDDVNFSVSRDDPTCF 336 Caenorhabditis e...
1KRM_A      235 LGHGYHTLEDt---------tLYNRLRQENMHFEICPWSSYLTGAWKpd------tEHAVIRFKNDQVNYSLNTDDPLIF 299 cow
1A4M_A      233 VGHGYHTIEDe---------aLYNRLLKENMHFEVCPWSSYLTGAWDpk------tTHAVVRFKNDKANYSLNTDDPLIF 297 house mouse

Feature 1                                                      
2ADA        301 KSTLDTDYQMTKKDmGFTEEEFKRLNINAAKSSFLPEEEKKELLERL 347 house mouse
ZP_00018439 295 AIDLPHEYRIARDRlGLTTEELRTLQAHALSAAFIDEATRAALLHKA 341 Chloroflexus aurantiacus
NP_872958   290 QTCIQQEYRLLAEQyQLSISEAKQLLLNSIAAAFLSNEDKKALLAHI 336 Haemophilus ducreyi 35000HP
NP_813973   285 DTTLTKEFMKLATWyQLSYDEMKQLTKNALAGAFLSPDEKKLLNQKI 331 Enterococcus faecalis V583
Q8E6I0      285 DTNLTKEYSLFVTYfGTKIEDFLVFNQNAVKASFTSDSEKDTLLHKL 331 Streptococcus agalactiae serogroup V
Q9X7T2      304 GTTMTREMSLLVEQaGWSVEDLRTVTVNALKSAFVPFDERTALIEDV 350 Streptomyces coelicolor
CAE15146    285 NITLCEEYLRINRYfGWQYSDFIETNLNALHASFSSNELKSRLEKEI 331 Photorhabdus luminescens subsp. laumondii TTO1
NP_501087   337 DNSMLSELTLVHKQiGLDVHQLWKAQLNAARSCFLPEDEKAELVKRV 383 Caenorhabditis elegans
1KRM_A      300 KSTLDTDYQMTKKDmGFTEEEFKRLNINAAKSSFLPEDEKKELLDLL 346 cow
1A4M_A      298 KSTLDTDYQMTKKDmGFTEEEFKRLNINAAKSSFLPEEEKKELLERL 344 house mouse